Press Release

June 08, 2022

BrainEver announces the award of €2.5M funding from the European
Innovation Council for its project on the use of homeoproteins as novel
therapies for neurodegenerative diseases


BrainEver’s project has been awarded a grant by the Horizon Europe funding program – the
ultra-competitive instrument EIC Accelerator. BrainEver is one of the 74 companies to win this
award at the March 2022 cut-off, selected amongst the 1092 projects filed. The project aims at
developing and validating a revolutionary therapy using the homeoprotein Engrailed-1, to treat
patients with Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s Disease (PD). BrainEver will
first receive €2.5M in grant to complete the regulatory preclinical toxicity studies and is eligible
to further negotiate up to €15M in equity from the EIC to lead the clinical validation on ALS and

Alain Prochiantz, co-founder and CSO, is the researcher that laid the foundation for BrainEver’s
technology, commented: “This award by the European Innovation Council illustrates how a
disruptive counter-dogmatic discovery, unveiling previously ignored physiological pathways, can
lead to the finding of therapeutic molecules with disease-modifying activities”.

November 23th, 2020

BrainEver Receives FDA Orphan Drug Designation for BREN-02, (human recombinant Engrailed 1) for theTreatment of Amyotrophic Lateral Sclerosis (ALS)


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« The homeoprotein ENGRAILED-1 promotes motoneuron survival and sustains motor functions »

BioRxiv (2019)

Vargas Abonce S., Lebœuf M., Moya K.L., Prochiantz A.

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“Homeoprotein Neuroprotection of EmbryonicNeuronal Cells”

eNeuro (2019), 6(5)

Vargas Abonce S., Leboeuf M., Prochiantz A., and Moya K.L.

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“Engrailed-1 induces long-lasting behavior benefit in an experimental Parkinson primate model”

Mov Disord (2019), Jul;34(7):1082-1084

Thomasson N., Pioli E., Friedel C., Monseur A., Lavaur J.,  Moya K.L.,  Bezard E., Bousseau A., Prochiantz A.

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“Non-cell autonomous OTX2 transcription factor regulates anxiety-related behaviors in the mouse”

BioRxiv (2019)

Vincent C., Gilabert-Juan J., Alvarez-Fischer D., Di Nardo A.A., Krebs M.-O., Le Pen A., Prochiantz A.

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“OTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis”

eNeuro (2019), 6(2)

Planques A., Oliveira Moreira V., Dubreuil C., Prochiantz A., and Di Nardo A.A.

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“Perineuronal nets in brain physiology and disease”

Seminars in Cell and Developmental Biology 89 (2019) 125–135

Testa D., Prochiantz A., Di Nardo A.A.

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“Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression”

The EMBO Journal (2018)

Blaudin de Thé FX., Rekaik H., Peze-Heidsieck E., Massiani-Beaudoin O., Joshi R.L., Fuchs J., Prochiantz A.

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“The Physiology of Homeoprotein Transduction”

Physiological Reviews (2018)

Di Nardo, A.A.,  Fuchs J., Joshi R.L., Moya K.L., Prochiantz A.

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“Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g”

Cerebral Cortex (2018), 1–12

Apulei J., Kim N., Testa D., Ribot J., Morizet D., Bernard C., Jourdren L., Blugeon C., Di Nardo A.A., Prochiantz A.

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“Extracellular Pax6 Regulates Tangential Cajal–Retzius Cell Migration in the Developing Mouse Neocortex”

Cerebral Cortex (2018), 1–12

Kaddour H., Coppola E., Di Nardo A.A., Le Poupon C., Mailly P., Wizenmann A., Volovitch M., Prochiantz A., Pierani A.

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 « Homeoprotein signaling in the developing and adult nervous system”

Neuron (2015)

Prochiantz A., Di Nardo A.A.

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“Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress”

Cell Reports (2015)

Rekaik H., Blaudin de Thé FX., Fuchs J., Massiani-Beaudoin O., Prochiantz A., Joshi RL.

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Posters presented at the Movement Disorder Society International congress, Sept. 2019

“Increasing chances of detecting a neuroprotective signal in PhI /II PD clinical”

Palfi S.,  Bousseau A., Denot C., and Corvol JC.

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“A single nigral injection of human ENGRAILED-1 induces long lasting behavior benefit in an experimental primate PD model”

Prochiantz A., Pioli E., Friedel C., Moya K.L., Bezard E., and Bousseau A.

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